目前的流行病学特征和ESBL产生的大肠杆菌在中国的健康动态
Sayyed Salman1, Zeeshan Umar2, Yonghong Xiao1
1Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, China.
产生扩展谱β-乳糖酶 (ESBL) 的大肠杆菌 (大肠杆菌) 在中国广泛蔓延. 抗生素的使用和人与动物的接触促进了这种传播,需要负责任的抗生素管理和有针对性的策略来控制耐药细菌.
科学领域:
- 微生物学 微生物学
- 公共卫生 公共卫生
- 环境科学 环境科学
背景情况:
- 扩展光谱β-乳糖酶 (ESBL) 产生的大肠杆菌在中国普遍存在.
- 传播与农业中的抗生素使用,动物便和人动物相互作用有关.
- 等离子体 (IncF,Inci,IncH) 和插入序列 (IS*26*,IS*1*) 驱动ESBL基因的水平基因转移.
研究的目的:
- 总结一下目前对中国ESBL产生大肠杆菌传播的理解.
- 确定导致抗生素耐药细菌 (ARB) 传播的关键因素.
- 突出塑和插入序列在ARG的演变和传播中的作用.
主要方法:
- 对中国的ESBL产生大肠杆菌现有文献的审查.
- 分析导致ARB传播的因素.
- 识别流行ESBL基因和移动遗传元素.
主要成果:
- *bla*CTX-M-14, *bla*CTX-15,和 *bla*CTX-M-55是人类,动物和环境部门中大肠杆菌中常见的ESBL基因.
- 这些基因经常与其他抗生素耐药性基因 (ARG) 共同定位.
- 质粒和插入序列在ARG的调动和传播中起着至关重要的作用.
结论:
- 积极的措施对于制ARB的传播至关重要.
- 谨慎使用抗生素和尽量减少与动物便的接触是关键的预防策略.
- 需要特定部门的教育策略来打击ESBL产生的大肠杆菌并保护公共健康.
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