手幻觉诱导的止痛的时间过程
Benjamin Mosch1, Xaver Fuchs2, Theresia Tu1
1Clinical and Experimental Behavioral Medicine, Department of Psychosomatic Medicine and Psychotherapy, LWL University Hospital, Ruhr University Bochum, Bochum, Germany.
Pain reports
|March 13, 2025
概括
视觉热手幻觉 (RHI) 增强了身体所有权,并减少了疼痛感知. 这项研究证实了RHI在调节疼痛方面的有效性,即使有不同的热刺激强度.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 疼痛感知 疼痛感知 疼痛感知
背景情况:
- 之前关于手幻觉 (RHI) 和其疼痛调节效应的研究产生了不一致的结果.
- 之前的研究使用了单独的刺激来诱导疼痛和RHI,可能会混焦点.
- 一种新的视觉热刺激方法整合了幻觉和疼痛刺激,以集中参与者的注意力.
研究的目的:
- 为了研究一个人造手的虚幻所有权期间疼痛调节的时间动态.
- 评估刺激强度对视觉热RHI范式内疼痛调节的影响.
- 评估虚幻的身体所有权对主观疼痛评级的影响.
主要方法:
- 具有2个条件 (RHI与控制) 和4个热刺激强度 (+0°C, -0.75°C, +0.75°C, +1.5°C) 的主体内设计.
- 参与者在手和隐藏的真实手上经历了同步的视觉热刺激.
- 使用滑动旋收集持续疼痛评级,控制试验采用旋转的手.
主要成果:
- 与对照组相比,在RHI条件下,体现评级明显高于对照组.
- 在大多数温度水平中,RHI条件下疼痛评级通常较低,除了+0.75°C外.
- 由于RHI的疼痛减轻在整个刺激期的大部分时间内都被观察到,不包括最初和最后的时刻.
结论:
- 视觉热RHI始终提高实施方案评级,无论温度如何.
- 这种幻觉在大部分刺激间隔期间与显著的疼痛减轻有关.
- 这些发现强调了RHI疼痛调节效应的稳定性和视觉热法的实用性.
相关概念视频
01:25Analgesia and Pain Management
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
01:15Opioid Analgesics: Synthetic and Semisynthetic Opioids
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
01:20Pain
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...