成人生长激素缺乏症 (AGHD) 和结果 (NordiNet和ANSWER)
John D Carmichael1, Atil Y Kargi2, Laura Dichtel3
1Endocrinology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA.
Journal of the Endocrine Society
|March 13, 2025
概括
短期生长激素替代疗法 (GHRT) 对所有年龄组的成年生长激素缺乏症 (AGHD) 患者是安全有效的. 现实数据证实IGF-I SDS水平的持续改善,并且在不良事件中没有显著差异.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- 成人生长激素缺乏症 (AGHD) 带来了重大的生理和心理挑战.
- 增长激素 (GH) 治疗可以缓解AGHD症状.
- 在不同成年年龄组中,关于长期GHRT有效性和安全性的现实数据至关重要.
研究的目的:
- 评估长期有效性和短效GH替代疗法 (GHRT) 的安全性,在患有AGHD的成年患者.
- 为了比较不同年龄层 (18-29,30-39,40-59岁) 的结果.
- 分析安全性和疗效指标,包括不良事件,IGF-I SDS,糖化血红蛋白和脂质资料.
主要方法:
- 来自NordiNet®国际结果研究和美国Norditropin®研究的现实数据的分析.
- 包括以前接受过治疗的和以前没有接受过治疗的AGHD患者.
- 在三个定义的年龄组中比较安全性 (不良反应/事件) 和有效性 (GH暴露,IGF-I SDS,HbA1c,非HDL胆固醇).
主要成果:
- 在年龄组之间没有观察到不良事件或不良反应发生率的统计学上显著差异.
- 平均胰岛素样生长因子-I标准偏差得分 (IGF-I SDS) 在2年内在所有组至少80%的患者中正常化 (达到2到2).
- 疗效结果表明,在研究的年龄群体中,疗效效益一致.
结论:
- 短期GHRT是一种安全有效的治疗选择,适用于广泛的成年年龄段的AGHD患者.
- 现实世界的证据支持GHT的长期疗效,常规化的IGF-I SDS水平始终保持一致.
- 这些发现补充了现有数据,加强了GHRT对所有成年AGHD患者群体的有用性.
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