用结肠镜检查和多目标便DNA (mt-sDNA) 测试进行结肠直肠癌查对环境的影响
Rebecca Alcock1,2, Aasma Shaukat3, John B Kisiel4
1Exact Sciences Corporation, Madison, WI 53719, United States.
Health affairs scholar
|March 13, 2025
概括
与结肠镜相比,多目标便DNA (mt-sDNA) 测试显著降低了结肠直肠癌 (CRC) 查的碳排放. 环境影响是选择CRC查策略的关键因素.
科学领域:
- 环境科学 环境科学
- 公共卫生 公共卫生
- 医疗技术 医疗技术 医学技术
背景情况:
- 医疗服务对碳足迹做出了重大贡献,需要进行环境影响评估.
- 结肠直肠癌 (CRC) 查指南提供多种模式,不同资源强度.
- 评估CRC查测试对环境造成的负担对于可持续的医疗保健至关重要.
研究的目的:
- 量化和比较两个主要的CRC查方法的环境负担:结肠镜和多目标便DNA (mt-sDNA) 测试.
- 评估与每个选模式相关的碳等价排放量,对大型队列进行评估.
- 通过将环境影响纳入CRC查策略的选择,为医疗保健决策提供信息.
主要方法:
- 利用经过验证的结肠直肠癌微型模拟模型,对100万名平均风险人群 (年龄在45-75岁) 进行了测试.
- 从2023年1月到2024年1月,收集了关于mt-sDNA和结肠镜的资源利用 (废物,能源,运输) 的数据.
- 将资源数据转换为碳等价排放量,包括选和后续程序.
主要成果:
- 查结肠镜需要比mt-sDNA更多的资源 (59%更高),即使包括后续程序.
- 后续结肠镜检查占 mt-sDNA查策略总排放量的大部分 (64%).
- 在 mt-sDNA 查中,与人口水平的结肠镜相比,碳排放显著减少.
结论:
- 多目标便DNA (mt-sDNA) 测试为结直肠癌查提供了比结直肠镜更低的碳足迹.
- 在选择指南推的CRC查选项时,环境影响应该是临床疗效之外的关键考虑因素.
- 将环境可持续性纳入选方式的选择可以减轻医疗保健部门的生态影响.
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