Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

MAPK Signaling Cascades01:07

MAPK Signaling Cascades

5.1K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
5.1K
Microtubule Associated Proteins (MAPs)01:42

Microtubule Associated Proteins (MAPs)

4.1K
Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are widespread across different organisms and have conserved protein motifs, like the multi-TOG domain for tubulin binding found in the CLASP family of MAPs. Some MAPs are lineage-specific based on their conserved domains. Their functions depend upon the cytoskeletal architecture and cell type they are located within. In-plant cells, a specific...
4.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Application of AI in Hypertension Health Education: Scoping Review.

Journal of medical Internet research·2026
Same author

Stable Emulsions Constructed From Whey Protein Isolate-Arabinogalactan Conjugates: Preparation, Characterization, and β-Carotene Loading.

Journal of food science·2026
Same author

Synergistic Effect of Hypertension and Smoking on Ischemic Stroke Risk: A Case-Control Study With Additive and Multiplicative Interaction Analysis.

Journal of visualized experiments : JoVE·2026
Same author

HSF1 acts as an endogenous protective mechanism in mechanically stretched alveolar epithelial cells.

Cell stress & chaperones·2026
Same author

Adipocyte-Derived Exosomal Circ_0000002 Affects the Myoblast Growth and Muscle Regeneration.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Deep eutectic solvent served as extractant and bio-activity enhancer: applications on curcuminoids extraction and food preservation.

Food chemistry·2026

相关实验视频

Updated: May 22, 2025

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
09:32

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

6.1K

3月2日通过调节PKM2聚合来缓解大动脉动脉瘤/剖析.

Yiran E Li1,2,3,4,5, Shuolin Liu1,2,6,3,4,5, Litao Wang1,2,3,4,5

  • 1Department of Cardiology, Shanghai Institute of Cardiovascular Diseases (Y.E.L., S.L., Litao Wang, Y.D., L. Wu, H.C., T.Z., J.L., S.X., L.L., J.G., J.R., Y.Z.), Zhongshan Hospital, Fudan University, China.

Circulation research
|March 13, 2025
PubMed
概括

3月2号通过防止血管光滑肌细胞亡,作为对大动脉动脉瘤和解剖 (AAD) 的保护因素. 针对March2可能为治疗AAD提供新的治疗策略.

关键词:
这是一种aminopropionitrile.一个大动脉动脉瘤.大动脉切割剖析.心血管疾病心血管疾病在任何地方都是无处不在的.

更多相关视频

Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms
07:42

Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms

Published on: July 26, 2024

1.3K
Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
06:14

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function

Published on: June 11, 2017

8.3K

相关实验视频

Last Updated: May 22, 2025

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
09:32

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

6.1K
Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms
07:42

Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms

Published on: July 26, 2024

1.3K
Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
06:14

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function

Published on: June 11, 2017

8.3K

科学领域:

  • 心血管生物学 心血管生物学
  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 大动脉动脉瘤/解剖 (AAD) 是一种严重的心血管疾病,药物治疗有限.
  • 蛋白质ubiquitination与心血管疾病有关,但在AAD中E3 ubiquitin ligaseMarch2的作用尚不清楚.

研究的目的:

  • 调查March2在AAD.病变发生过程中的作用.
  • 探索March2调节血管光滑肌肉细胞亡的机制及其作为治疗点的潜力.

主要方法:

  • 在人类AAD组织上集成的单细胞RNA测序.
  • 生成特定于光滑肌细胞的March2淘汰赛小鼠模型.
  • 使用β-aminopropionitrile monofumarate诱导AAD并评估March2的作用.
  • 使用CUT&Tag-qPCR.分析基因组H3K18乳化点.

主要成果:

  • 在人类和小鼠AAD模型中,March2表达减少.
  • 3月2日缺陷加剧了AAD,而其恢复则拯救了病理.
  • 3月2日与PKM2相互作用,影响K33结合的多基化,并减轻ADD诱导的基H3K18乳化.
  • 激活PKM2可以缓解March2缺陷引起的AD严重性.

结论:

  • 3月2日通过抑制血管光滑肌肉细胞亡,作为对AAD的内源性保护因素起作用.
  • 3月2日成为治疗大动脉动脉瘤和剖析的有前途的治疗点.