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Updated: May 11, 2026

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在现场用光亲和化学探针标记致病性

Pengju Nie1, You Wu1,2, John Robinson3

  • 1Chemical Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States.

ACS chemical biology
|March 13, 2025
PubMed
概括

研究人员开发了新的光亲和探针,在阿尔茨海默病 (AD) 模型和患者大脑中专门标记tau蛋白. 这些工具有助于理解病症,并开发针对神经退行性疾病的向治疗方法.

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Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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In-situ Hybridization

In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...