使用Yarrowia lipolytica生物技术生产胡卜素
Jie Mai1, Aiqi Liu1, Wenjuan Li1
1State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30 South Puzhu Road, Nanjing 211816, People's Republic of China.
Journal of agricultural and food chemistry
|March 13, 2025
概括
这篇综述探讨了使用人工酵母,Yarrowia lipolytica的卡洛酸生产. 它强调了生物技术战略和可持续的胡卜素生物合成的未来前景.
科学领域:
- 生物技术和合成生物学
- 微生物发酵过程中的微生物发酵.
- 自然产品化学 自然产品化学
背景情况:
- 胡卜素是重要的四烯酸,具有多种工业应用.
- 工程微生物发酵为胡卜素生产提供了一个可持续的途径.
- 雅罗维亚脂质菌 (Yarrowia lipolytica) 是一个有希望的油性酵母宿主,用于胡卜素生物合成.
研究的目的:
- 审查关键类胡卜素的功能,如利科,β-胡卜素和阿斯塔克桑丁.
- 在Y. lipolytica.中对胡卜素生产的生物技术策略进行分类和总结.
- 展望未来的策略,以提高Y. lipolytica.中的胡卜素产量.
主要方法:
- 关于胡卜素功能和生物合成途径的文献综述.
- 对Y. lipolytica.的基因工程和发酵技术的分析.
- 综合当前的进展和未来的研究方向.
主要成果:
- Y. lipolytica 对于生产胡卜素具有固有的优势.
- 为了在这种酵母中合成胡卜素,已经开发了各种生物技术策略.
- 该审查提供了当前生产方法的全面概述.
结论:
- Y. lipolytica 是一个非常适合的宿主,可以有效和可持续地生产胡卜素.
- 进一步优化代谢途径和发酵条件可以显著提高产量.
- 持续的研究有望扩大微生物衍生的胡卜素的工业应用.
相关概念视频
Transgenic Plants
7.1K
Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...
7.1K
Plant Breeding and Biotechnology
18.7K
Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.
18.7K
Synthetic Biology
4.7K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Golden rice
Golden rice is a genetically modified...
4.7K
Transgenic Organisms
30.8K
Overview
30.8K
The Calvin Benson Cycle
4.4K
Ribulose 1,5- bisphosphate carboxylase/oxygenase (RuBisCo) is a critical enzyme that catalyzes carbon dioxide assimilation during photosynthesis. However, it is an inefficient enzyme, having an extremely slow catalytic rate. A typical enzyme can process about a thousand molecules per second; however, RuBisCo fixes only around three-carbon dioxides per second. Photosynthetic cells compensate for this slow rate by synthesizing very high amounts of RuBisCo, making it the most abundant single...
4.4K


