睡眠时间,中点,可变性,不规则性和与代谢功能障碍相关的脂肪性肝病
Qingcui Wu, Fuman Song, Huijie Huang1
1School of Public Health, Tianjin Medical University, Tianjin, China.
Behavioral sleep medicine
|March 13, 2025
概括
睡眠不规则和睡眠时间短暂增加了与代谢功能障碍相关的脂肪性肝病 (MASLD) 的风险. 这些睡眠参数应在MASLD预防策略中考虑.
科学领域:
- 睡眠科学 睡眠科学
- 肝病学 肝病学是一种肝病学.
- 代谢健康 代谢健康
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,是一个日益严重的健康问题.
- 睡眠模式和MASLD风险之间的联系尚未完全理解.
- 动图学提供了对睡眠持续时间和变化的客观测量.
研究的目的:
- 调查动图学衍生睡眠参数与MASLD风险之间的关联.
- 探索睡眠时间,中点,可变性和不规则性如何与MASLD相关.
- 为了确定可能预测MASLD发展的特定睡眠特征.
主要方法:
- 利用了2011-2014年国家健康和营养检查调查 (NHANES) 的数据.
- 评估睡眠时间和中点,使用4-7天的动图.
- 根据多社会德尔菲共识和脂肪肝指数根据脂肪肝指数定义的MASLD.
- 用多变量加权后勤回归来进行相关性和子组分析.
主要成果:
- 睡眠时间短 (<7小时) 与24%的MASLD风险增加有关.
- 睡眠不规则性增加 (中点的标准偏差) 显示出一个显著的趋势, MASLD 风险更高 (趋势的P = .003).
- 睡眠变化也显示出对MASLD风险增加的趋势,特别是偏差>90分钟 (P趋势=0.034).
结论:
- 睡眠时间是与MASLD风险相关的重要因素.
- 除了睡眠时间之外,睡眠不规则也成为预防MASLD的关键因素.
- 未来的研究应该考虑睡眠时间和MASLD管理策略中的不规则性.
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