在美国三个艾滋病毒诊所中确定长效注射性卡博特格拉维尔-里尔普维林的首选方案交付属性:一个离散选择实验
Jose I Gutierrez1, Elizabeth T Montgomery2,3, Samantha E Dilworth4
1Department of Family Health Care Nursing, School of Nursing, University of California San Francisco, San Francisco, California, USA.
Journal of acquired immune deficiency syndromes (1999)
|March 13, 2025
概括
长效注射性卡博特格拉维尔和里尔皮维林 (CAB/RPV-LA) 是艾滋病毒感染者 (PWH) 最喜欢的药物,如果免费提供,并在他们当前的诊所提供. 需要针对不同患者需求量身定制的交付计划,特别是那些参与度低于最佳的患者.
科学领域:
- 艾滋病毒/艾滋病治疗的坚持
- 药物经济学和医疗保健提供
背景情况:
- 长效注射卡博特格拉维尔和里尔皮维林 (CAB/RPV-LA) 为艾滋病毒感染者 (PWH) 提供了一种新的治疗选择.
- 了解影响CAB/RPV-LA吸收的因素对于成功实施至关重要.
研究的目的:
- 调查患者对长效注射性艾滋病毒治疗特征的偏好.
- 为了确定能够在多样化的PWH群体中促进CAB/RPV-LA使用的关键因素.
主要方法:
- 在三个城市的美国艾滋病毒诊所中,对370个PWH进行了离散选择实验 (DCE).
- DCE评估了包括成本,访问位置,提供者互动,支持服务,访问长度和延长时间在内的属性.
- 混合逻辑回归和隐性类分析被用于确定偏好权重和识别不同的患者群体.
主要成果:
- 费用和访问地点是影响治疗选择的最重要因素.
- 确定了三个偏好群体:成本意识 (44%),位置驱动 (34%) 和面向提供商/支持服务 (22%).
- 低于最佳的PWH参与者表示他们更喜欢增强的支持服务.
结论:
- 当它是免费的,并在他们现有的艾滋病毒诊所提供时,PWH强烈喜欢CAB/RPV-LA.
- 普华永道的异质偏好,特别是那些参与度低于最佳的偏好,凸显了个性化和灵活的交付模式的需要.
- 根据患者偏好优化交付策略可以显著增加CAB/RPV-LA利用率,在首选情景中可能超过80%.
相关概念视频
Drug Delivery: Miscellaneous Routes
299
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
299
Drug Delivery: Overview
270
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
270
Routes of Drug Administration: Parenteral
1.8K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
1.8K
Additional Routes of Drug Administration
2.7K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
2.7K
Drug Delivery: Parenteral Route
357
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
357
Retrovirus Life Cycles
45.5K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.5K


