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使用皮肤和药物挑测试对立即基于的对比介质过敏反应的客观评估
Si Min Chiow1, Pearlyn Mei Ping Wong1, Martin Weng Chin H'ng1
1Department of Diagnostic Imaging, Tan Tock Seng Hospital, Singapore, Singapore.
Acta radiologica (Stockholm, Sweden : 1987)
|March 13, 2025
概括
对基对比介质 (ICM) 过敏的客观测试,包括皮肤测试和药物诱导测试 (DPT),有助于管理患者的护理. 约迪克桑醇在测试的ICM中表现出最低的交叉反应性,使其能够安全地重新注射.
科学领域:
- 放射学 放射学是一门学科.
- 过敏和免疫学 过敏和免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 基于的对比介质 (ICM) 在放射学中至关重要.
- 怀疑ICM过敏显著影响患者管理.
- 客观的过敏测试可以指导安全的ICM管理.
研究的目的:
- 皮肤测试与ICM过敏的药物诱导测试 (DPT) 结果相关联.
- 确定三种常用的ICM之间的交叉活性.
- 在负面的客观测试后评估ICM再暴露的安全性.
主要方法:
- 怀疑ICM过敏的患者接受了皮肤测试和/或DPT.
- 在ICM再暴露后对CT扫描中的反应的后续评估.与对比增强的CT扫描.
- 皮肤测试和DPT之间的一致性分析,以及ICM交叉反应性的评估.
主要成果:
- 测试包括72名患者;一致性因ICM而异 (例如,iohexol的85.7%,iodixanol的65.1%).
- 不同ICM之间的交叉反应率从43.3%到77.4%不等.
- 在14名患者中,只有1名患者在检测中呈阴性反应,在重新暴露时反应.
结论:
- 对ICM过敏的客观测试,特别是在暴露后6个月内,有助于安全地使用ICM.
- 大多数患者可以在测试后接受ICM,而不会出现不良反应.
- 约迪克桑醇在评估的ICM中表现出最低的交叉反应性.
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