左心室缩和慢性病之间的双向联系. 一个交叉滞后分析分析
Eva Ntounousi1, Graziella D'Arrigo2, Mercedes Gori3
1University Hospital of Ioannina, Ioannina, Greece.
Journal of hypertension
|March 13, 2025
概括
降低功能 (eGFR) 显著预测慢性病 (CKD) 患者的左心室缩 (LVH) 恶化. 然而,增加的LVH并不能预测降低的eGFR,这表明脏病驱动心脏变化比心脏病驱动脏变化更多.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 内部医学 内部医学
背景情况:
- 心力衰竭 (HF) 与减少的淋巴膜过率 (GFR) 有关.
- 慢性病 (CKD) 增加左心室缩 (LVH) 和HF的风险.
- 关于CKD和LVH进展之间的双向关系的研究有限.
研究的目的:
- 在CKD患者中研究估计的GFR (eGFR) 和左心室质量指数 (LVMI) 之间的纵向关系.
- 为了确定eGFR下降是否预测LVH进展,反之亦然.
- 了解功能与心脏重塑在CKD中的相互作用.
主要方法:
- 一组106名CKD患者 (G1-5阶段) 在三年内进行了研究.
- 一个交叉滞后模型分析了257个配对的LVMI和eGFR测量.
- 模型根据以前的值进行调整,以确保准确的纵向评估.
主要成果:
- 在eGFR下降1ml/min/1.73m2预测LVMI增加1.12g/m2 (P<0.001).
- 高的LVMI并没有显著预测随着时间的推移eGFR的减少.
- 在基线时,LVH在62%的患者中流行 (EGFR中位数:54毫升/分钟/1.73米2).
结论:
- 在CKD患者中,GFR损失显著预测LVH恶化.
- 由脏疾病驱动的心肌病的风险可能超过由心脏病驱动的CKD进展的风险.
- 监测功能对于控制慢性病中心血管风险至关重要.
更多相关视频
07:38Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
Published on: January 20, 2023
3.4K
07:41A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
Published on: March 1, 2022
2.9K
相关概念视频
01:33Hormonal Regulation
32.8K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.8K
01:17Pathophysiology of Heart Failure
1.4K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.4K
01:22Heart Failure Drugs: Diuretics
313
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
313