夜间的血压向的抗高血压治疗
Tatsuya Maruhashi1, Yoshihiko Kinoshita2, Ryoji Ozono3
1Department of Regenerative Medicine, Division of Radiation Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University.
Journal of hypertension
|March 13, 2025
概括
用积极的抗高血压药物调整准夜间血压 (BP),在六个月内,在一半以上的接受药物治疗的患者中,安全地使夜间高血压正常化. 这种方法也降低了早上和晚上血压水平.
科学领域:
- 心脏病学 心脏病学
- 高血压管理 高血压管理
- 药物治疗 药物治疗
背景情况:
- 夜间高血压是一种已知的心血管风险因素.
- 有限的数据存在于改善结果通过准夜间血压 (BP) 在药物治疗高血压患者.
- 这项研究解决了对调整夜间高血压治疗的抗高血压治疗的有效性和安全性的理解上的差距.
研究的目的:
- 调查针对夜间血压的激进抗高血压药物调整是否可以使服药患者的夜间高血压正常化.
- 为了评估这种治疗方法的安全性.
- 评估对早上和晚上血压水平的影响.
主要方法:
- 一项前性多中心研究,涉及264名接受药物治疗的高血压患者 (平均年龄68.5岁).
- 家庭血压监测在基线和6个月用于测量夜间血压.
- 患有夜间高血压 (夜间SBP≥120mmHg) 的患者接受了针对夜间BP的积极治疗调整.
主要成果:
- 在264名患者中,有90人在基线时患有夜间高血压.
- 6个月后,这些患者中53.3% (48/90) 的夜间高血压正常化.
- 观察到早上和晚上BP的显著降低,没有治疗特异性的不良事件.
结论:
- 针对夜间血压的积极的抗高血压药物治疗调整可以在超过一半的药物治疗患者中安全地使夜间高血压正常化.
- 夜间高血压的正常化是在6个月内实现的.
- 这一策略提供了一种安全有效的管理夜间高血压的方法,并可能降低心血管风险.
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