症状性外周动脉疾病下肢重大截肢的危险因素:一个回顾性队列研究
Supatcha Prasertcharoensuk1, Krittin Prateepphuangrat1, Phati Angkasith1
1Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Future science OA
|March 13, 2025
概括
周围动脉疾病 (PAD) 患者面临重大截肢风险. 拉瑟福分类,白细胞计数和血清白蛋白水平是关键预测因素. 降低血清白蛋白可能有助于预防截肢.
科学领域:
- 血管外科 血管外科
- 临床医学 临床医学
- 流行病学 流行病学
背景情况:
- 周围动脉疾病 (PAD) 是致病率的一个重要原因.
- 重大截肢是PAD患者的严重并发症.
- 识别风险因素对于预防策略至关重要.
研究的目的:
- 为了确定症状PAD患者大截肢的独立风险因素.
- 分析个人风险因素和治疗对截肢风险的综合影响.
- 探索可修改的因素,以防止PAD的主要截肢.
主要方法:
- 追溯队列研究的设计.
- 包括被诊断患有症状PAD的成年患者.
- 统计分析以确定重大截肢的预测因素.
主要成果:
- 分析了221名PAD患者;12.67%的患者经历了重大截肢.
- 确定了独立的预测因素:拉瑟福分类 (aOR 1.824),白细胞计数 (aOR 1.073),以及血清白蛋白 (aOR 0.421).
- 较高的拉瑟福分类和白细胞计数增加了截肢风险,而较高的血清白蛋白则降低了这一风险.
结论:
- 拉瑟福分类,白细胞计数和血清白蛋白是PAD重大截肢的独立预测因素.
- 血清白蛋白是一种可修改的因素,可以针对性地预防重大截肢.
- 这些发现可以为PAD管理和风险分层的临床实践提供信息.
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