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系统性免疫炎症指数是一个独立的预测因素,可以预测慢性肢体威胁性缺血症的主要截肢

Ahmet Can Çakmak¹, Mehmet Bülent Vatan², Betul Sarıbıyık Çakmak²

¹Department of Cardiology, Sakarya University Education and Research Hospital, Sakarya, Turkey.

|March 13, 2025

概括

高系统性免疫炎症指数 (SII) 预测了下肢外周动脉疾病 (LEAD) 患者的主要截肢风险. 这种简单的标志物有助于指导肢体救援的治疗决策.

科学领域:

血管外科血管外科
炎症生物标志物炎症生物标志物
截肢预防防止截肢

背景情况:

下肢周围动脉疾病 (LEAD) 包括动脉狭窄和封闭,慢性四肢威胁性缺血症 (CLTI) 代表其最严重的形式.
CLTI显著增加了重大截肢的风险.
系统性免疫炎症指数 (SII) 由中性粒细胞,淋巴细胞和血小板数量得出的,反映了患者的炎症和免疫血栓状况.

研究的目的:

研究LEAD患者系统性免疫炎症指数 (SII) 的升高与主要四肢截肢的可能性之间的关联.
评估SII作为预测性生物标志物,在这个患者群体中预测重大截肢.

主要方法:

分析了一组140名患有Rutherford 5或6 LEAD的患者和接受内血管干预的脚伤.
收集了人口和实验室数据,包括中性粒细胞与淋巴细胞的比率,血小板与淋巴细胞的比率和SII.
采用接收器运行特征 (ROC) 曲线分析和后勤回归来评估SII对重大截肢的预测值.

主要成果:

在19.2% (27/140) 的患者中,需要进行重大截肢.
经过大截肢的患者表现出显著更高的中性粒细胞与淋巴细胞的比率,血小板与淋巴细胞的比率和SII值.
在ROC分析中,SII切断值为1018被认为是预测大截肢的最佳值 (AUC:0.84,灵敏度:81%,特异性:73%).
后勤回归证实高SII是主要截肢的独立预测因素 (OR = 1.001,p = .009).

结论:

升高的SII与患有脚伤的LEAD患者的大型截肢风险的增加显著相关.
SII作为一个有价值和易于获取的生物标志物,用于预测重大截肢风险.
这些发现表明,SII可以帮助临床医生做出明智的治疗决策,以保护LEAD患者的肢体.

关键词:

系统性免疫炎症指数慢性四肢威胁性缺血症是什么这是一次严重的截肢.

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