在HPV相关的口腔膜状细胞癌中,预治疗液体活检和临床病理特征
Peter V Cooke1, Susmita Chennareddy1, Daniel O Kraft1
1Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York.
JAMA otolaryngology-- head & neck surgery
|March 13, 2025
概括
在HPV阳性口腔状状细胞癌患者中,循环瘤组织病毒修饰的HPV (TTMV-HPV) DNA的较高水平与更先进的疾病阶段和更大的瘤负担相关. 需要进一步的研究来确定TTMV-HPVDNA水平是否可以指导治疗决策.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 遗传学 是一个遗传学.
背景情况:
- 阳性HPV口腔状细胞癌 (HPV+OPSCC) 的预后有利,但在保持低复发率的同时降低治疗升级是具有挑战性的.
- 确定HPV+OPSCC可靠的预后因素对于完善治疗策略至关重要.
- 治疗前循环瘤组织病毒修饰型HPV (TTMV-HPV) DNA水平可能会提供有关疾病负担和预后的见解.
研究的目的:
- 研究HPV+OPSCC患者治疗前TTMV-HPVDNA水平与临床,放射学和组织病理学特征之间的关联.
- 探索TTMV-HPVDNA水平与患者的结果之间的关系,包括无复发和疾病特异性存活率.
主要方法:
- 进行了一项对203名HPV+OPSCC患者的队列研究,这些患者在预治疗前获得了TTMV-HPVDNA片段测试结果.
- TTMV-HPV的DNA片段水平被分为低 (≤99片段/毫升),中等 (100-999/毫升) 和高 (≥1000/毫升) 的队列.
- 分析了与临床阶段 (cT,cN) 的关联,PET-CT特征,组织病理特征和生存结果.
主要成果:
- 较高的TTMV-HPVDNA水平与更先进的临床瘤 (cT2,cT3/4) 和结节 (cN1,cN2/3) 阶段明显相关.
- 增加的TTMV-HPVDNA水平与PET-CT上更高的总原发性瘤加结节体积相关.
- 在TTMV-HPV DNA水平和组织病理特征 (淋巴血管入侵,围神经入侵,外节延伸) 或生存结果之间没有发现显著的关联.
结论:
- 较高的治疗前TTMV-HPVDNA片段水平与HPV+OPSCC的更先进的临床阶段和更大的瘤体积有关.
- 这些发现表明,TTMV-HPV DNA可能作为HPV+ OPSCC.的疾病负担的潜在生物标志物.
- 需要进一步的研究来探索治疗前TTMV-HPVDNA水平在指导HPV+OPSCC治疗决策中的有用性.
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