在吸烟和非吸烟妇女中,高糖含糖饮料摄入量和口腔腔癌
Luis Gomez-Castillo1, Kara L Cushing-Haugen2, Mateo Useche3
1University of Washington School of Medicine, Seattle.
JAMA otolaryngology-- head & neck surgery
|March 13, 2025
概括
高糖甜饮料 (SSB) 摄入量显著增加女性口腔癌 (OCC) 的风险. 这一发现甚至适用于非吸烟者和轻度饮酒者,突出了潜在的公共卫生问题.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 全球口腔癌 (OCC) 发病率正在上升,特别是在没有传统风险因素的个体中.
- 含糖饮料 (SSB) 的消费与各种癌症有关,但其与OCC的特定关联仍未得到充分探索.
研究的目的:
- 调查SSB消费与OCC风险之间的关系.
- 分析这一关联在大量女性群体中,考虑吸烟和饮酒习惯.
主要方法:
- 一项使用护士健康研究 (NHS) 和NHSII.II数据的纵向队列研究.
- 分析包括超过162,000名妇女,追踪30年来SSB摄入频率和OCC诊断.
- 考克斯比例危险回归模型用于评估危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 每天摄入一个或多个SSB的女性,与每月摄入不到一个SSB的女性相比,OCC的风险增加了4.87倍.
- 在非吸烟者或轻度吸烟者和非饮酒者或轻度饮酒者分组中也观察到这种高风险,风险高5.46倍.
- 尽管风险增加,但研究群体中OCC的基线发病率很低.
结论:
- 高SSB摄入量显著与女性OCC风险增加有关.
- 在SSB摄入量和OCC风险之间的关联是独立于吸烟和饮酒状态.
- 需要对包括男性在内的更大,多样化的队列进行进一步的研究,以证实这些发现及其更广泛的影响.
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