艾滋病毒对呼吸系统症状,健康状况和运动能力的影响:系统性审查和元分析
Ioannis Konstantinidis1,2, Spyridon N Papageorgiou3, Richard H Zou1
1Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
AIDS (London, England)
|March 13, 2025
概括
艾滋病毒感染者 (PLWH) 经历更严重的呼吸系统症状和减弱的运动能力. 建议对患者报告结果 (PROs) 进行例行评估,以便在PLWH中早期检测肺部疾病.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 艾滋病毒感染者 (PLWH) 患肺功能减弱和肺气的风险更高.
- 人们越来越认识到艾滋病毒是影响呼吸系统患者报告结果 (PROs) 的潜在风险因素.
研究的目的:
- 评估艾滋病毒状况与呼吸系统症状之间的关联.
- 评估艾滋病毒对呼吸系统健康状况的影响.
- 为了确定艾滋病毒对功能性运动能力的影响.
主要方法:
- 进行了系统审查和元分析,搜索了多个数据库,直到2023年11月.
- 包括的研究报告了艾滋病毒感染者和未感染者的呼吸道PRO.
- 主要结局包括活动限制性呼吸障碍,圣乔治呼吸道问卷 (SGRQ) 分数和六分钟步行距离 (6MWD).
主要成果:
- 艾滋病毒与活动限制性呼吸不全 (OR 1.67) 和较差的呼吸系统健康状况 (SGRQ MD 2.9 单位) 有显著的关联.
- 在PLWH (6MWD MD -58.9米) 中,运动能力降低,慢性咳,呼吸不全,和喘息的几率增加 (OR 1.38-1.78).
- 在欧洲PLWH中观察到呼吸道症状和不良健康状况的风险最高;证据确定性非常低.
结论:
- 感染艾滋病毒的人面临着更糟糕的呼吸系统患者报告结果的风险.
- 将系统的呼吸道PRO评估整合到日常护理中,可以帮助识别PLWH的慢性肺病.
- 未来的研究应该同时检查客观的生理测量和呼吸器PROs随着时间的推移.
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