了解胰岛素抵抗和认知之间的联系:在城市,南印度队列中进行的一项横截面研究
Anjana J Menon1, Monisha Selva1, G Sandhya1
1Centre for Brain Research, IISc Bangalore, Indian Institute of Science Campus, CV Raman Avenue, Bangalore, 560012, India.
胰岛素耐药性 (IR) 与较差的听觉注意力和单词理解有关. 这种代谢风险因素也与关键区域的大脑体积减少有关,影响认知功能.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 认知科学 认知科学
背景情况:
- 由胰岛素抵抗 (IR) 引起的代谢失调可能会对认知产生负面影响.
- 红外线越来越被认为是一个重要的代谢风险因素.
- 了解IR在认知衰退中的独立作用至关重要.
研究的目的:
- 研究胰岛素抵抗 (IR) 作为对认知表现的独立代谢风险.
- 探索非痴呆成年人的IR和认知功能之间的关联.
- 检查IR与大脑结构变化之间的关系.
主要方法:
- 来自塔塔长度老龄化研究 (TLSA) 的1072名非痴呆症参与者 (年龄≥45岁).
- 快速胰岛素和葡萄糖的评估,以使用HOMA-IR计算IR.
- 使用COGNITO神经心理测试电池评估认知功能.
- 通过3特斯拉MRI进行脑成像,并使用Freesurfer进行皮质体积分析.
- 一般化线性回归模型 (GLM) 用于统计分析.
主要成果:
- 在研究队列中,IR的患病率为56.3%.
- IR与听觉注意力 (p=0.014) 和词汇理解能力 (p=0.043) 的降低显著相关.
- 磁力共振成像分析显示,红外线与左桃体,叶,轨道前皮层,胰岛和右前皮质的大脑体积减少有关.
结论:
- 胰岛素抵抗 (IR) 与较差的听觉注意力和认知表现显著相关.
- 红外线与特定区域的大脑体积的减少有关,这突显了它对大脑结构的影响.
- 这些发现强调了新陈代谢健康在维持认知功能的重要性.
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