2000-2020年胃腺癌与年龄相关的差异:A SEER数据库分析分析
Abdul Qahar Khan Yasinzai1,2, Anwaar Saeed3,4
1Department of Medicine, Division of Medical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, 15232, USA.
Journal of gastrointestinal cancer
|March 13, 2025
概括
胃腺癌 (GAC) 影响的是老年人,但早期发病的病例表现出侵略性特征和糟糕的生存率,特别是在西班牙裔人口中. 黑人个体在所有年龄组中经历了最糟糕的生存结果,突出了对特定年龄的干预措施的需要.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 医学统计 医学统计
背景情况:
- 胃癌 (GC) 是全球癌症死亡的主要原因,腺癌 (GAC) 占95%的病例.
- 虽然GAC通常影响老年男性,但在不同年龄段存在显著的人口和预后差异.
- 了解这些与年龄相关的差异对于有效的GAC管理至关重要.
研究的目的:
- 为了比较不同年龄组的胃腺癌 (GAC) 患者的人口特征和预后结果.
- 为了确定特定年龄的风险因素和GAC的生存趋势.
- 为不同患者的人口统计学特制干预措施的开发提供信息.
主要方法:
- 从监测,流行病学和最终结果 (SEER) 计划 (2000-2020) 中对103,674个GAC病例进行了回顾性分析.
- 为了进行比较分析,病例被分为不同的年龄段.
- 评估了人口统计数据,瘤特征和生存结果.
主要成果:
- GAC患者的平均年龄为69岁;39.7%的患者年龄在66-80岁之间.
- 年轻人 (<35岁) 和老年人 (≥81岁) 群体的女性比例较高.
- 在年轻的GAC患者中,西班牙裔种族更为普遍,而非西班牙裔白人种族则主导了最年长的群体.
- 肝转移在51-65岁和66-80岁的年龄组中更常见.
- 早期发病的GAC (<35岁) 经常出现在心脏.
- 男性性别和黑人种族与所有年龄段的最糟糕的生存结果有关,特别是在最年轻的群体中.
- 西班牙裔患者在年轻时的生存率较低,但在最年长组 (≥81岁) 的生存率更高.
- 瘤的位置 (较大的曲率,重叠的病变) 和组织学影响了预后.
结论:
- 胃腺癌主要影响美国的老年人,但早期发病的胃腺癌表现出侵略性特征和较差的生存率,特别是在西班牙裔人口中.
- 黑人个人在所有年龄段都面临着最严重的生存挑战.
- 在极端的年龄阶段,性别分布有所不同.
- 随着各年龄组的人口和预后的显著变化,需要定制GAC治疗策略.
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