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通过FABP5-mTORC1信号直接检测食中的 ω-6 氨酸

Nikos Koundouros^1,2, Michal J Nagiec^1,2, Nayah Bullen¹

¹Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Science (New York, N.Y.)

|March 13, 2025

概括

科学家们发现了细胞如何感知饮食中的脂肪,并确定了一条涉及脂肪酸结合蛋白5 (FABP5) 和由omega-6酸 (LA) 激活的拉巴胺素复合体1 (mTORC1) 的机制性点的途径. 这一发现可能为乳腺癌提供了一个新的生物标志物.

科学领域:

细胞生物学
营养感应机制
癌症研究

背景情况:

细胞对葡萄糖和氨基酸的感知是可以理解的,但对脂质的感知却不那么清楚.
饮食中的脂质在细胞功能和信号通路中起着至关重要的作用.
脂肪酸结合蛋白5 (FABP5) 与细胞脂质代谢有关.

研究的目的:

阐明细胞感知食脂质的分子机制.
研究FABP5在营养信号通路中的作用.
探索FABP5作为乳腺癌生物标志物的潜力.

主要方法:

研究了FABP5和mTORC1组件之间的相互作用.
使用生物化学测试来研究蛋白质结合和复合物形成.
在乳腺癌患者样本中分析FABP5蛋白水平.

主要成果:

确定了一种新的信号通路,其中FABP5直接与Raptor结合,增强mTORC1的形成和活性.
证明这种途径是由多不和脂肪酸omega-6氨酸 (LA) 激活的.
与受体阳性乳腺癌相比,在三阴性乳腺癌和血清中观察到高FABP5水平.

结论:

FABP5 是细胞对omega-6 LA反应的关键调解者,影响mTOR信号传递和增殖.
FABP5-mTORC1轴代表了饮食中的脂质摄入量与癌细胞生长之间的关键联系.
FABP5 显示为三阴性乳腺癌的诊断生物标志物,与疾病状态和omega-6 LA代谢相关.

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