习惯的电路是如何在基底腺节内形成的
1Department of Neuroscience, Karolinska Institutet, Stockholm SE17177, Sweden.
概括
习惯需要大脑皮层来学习,但背侧条纹体 (DLS) 和基底质回路随后管理它们. 在DLS突触中由多巴胺驱动的强化加强了成功的运动序列.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 学习和记忆的学习和记忆
背景情况:
- 刻板印象的运动序列 (习惯) 最初取决于皮质参与学习.
- 一旦学习,习惯的表现是独立于皮质,依赖于感觉运动通路.
- 脊侧条纹体 (DLS),黑色质部分网状体 (SNr) 和状细胞核 (PF) 构成一个关键的基底质回路,用于运动控制.
研究的目的:
- 提出一个模型,说明习惯运动程序在学习阶段之后如何维持和执行.
- 阐明背侧条纹体 (DLS) 和其相互连接的基底结环在习惯形成和表现中的作用.
- 解释在成功的,奖励的运动序列执行过程中,在DLS内突触增强的机制.
主要方法:
- 审查和综合最近关于基底腺节电路和习惯形成的发现.
- 分析DLS-SNr-PF-DLS循环中的空间组织和功能相互作用.
- 基于突触可塑性和奖励介导的增强功能的理论建议.
主要成果:
- DLS-SNr-PF-DLS循环被组织成平行子电路.
- 这些平行循环的目的是加强条状投射神经元的活动.
- 在DLS中,通过多巴胺爆发的成功,奖励的运动序列表现来增强突触传输.
结论:
- 通过并行循环和突触强化,DLS-SNr-PF-DLS电路是学习运动序列的基础.
- 在学习之后,这种基底质回路可以自主运行,独立于皮质输入.
- 这些发现凸显了背侧条纹体在巩固和执行习惯方面的关键作用.
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