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基于人口的估计,孟加拉国肝炎E病毒相关死亡率

Repon C Paul^1,2, Heather F Gidding^3,4, Arifa Nazneen¹

¹icddr,b, Dhaka, Bangladesh.

The Journal of infectious diseases

|March 13, 2025

概括

甲型肝炎病毒 (HEV) 在孟加拉国造成显著的死亡率,每年大约有986例成年人死亡,大量死产和新生儿死亡. 这项研究为评估HEV疫苗接种策略提供了关键数据.

科学领域:

公共卫生公共卫生
传染性疾病传染性疾病
流行病学流行病学

背景情况:

肝炎E病毒 (HEV) 是资源贫困地区的重大公共卫生问题.
关于HEV特异性死亡率的准确数据有限,影响公共卫生决策.
孟加拉国面临着高高温病毒的高负担,需要精确的死亡率估计.

研究的目的:

估计孟加拉国基于人口的HEV特定死亡率.
为评估HEV干预措施 (包括疫苗接种) 的成本效益提供数据.

主要方法:

从2014年12月到2017年9月,在6家三级医院对急性黄患者 (≥14年) 的监测.
在注册患者中检测IgM抗HEV抗体.
在医院采集区进行死亡率调查,以确定与黄相关的死亡,包括孕产妇,死胎和新生儿死亡,使用口头尸检数据.

主要成果:

估计每年在孟加拉国成年人 (≥14岁) 中,HEV相关死亡人数为986 (95% CI:599-1338).
每年大约有163 (95% CI: 57-395) 个由HEV引起的孕产妇死亡.
另外每年有279 (95% CI: 101-664) 死亡出生和780 (95% CI: 365-1,297) 新生儿死亡与HEV感染有关.

结论:

这项研究提供了孟加拉国首次直接,基于人口的HEV死亡率估计.
这些发现与之前对HEV相关死亡的广泛变化的建模估计形成鲜明对比.
这些数据对于通知E型肝炎疫苗接种和其他公共卫生干预措施的成本效益至关重要.

关键词:

乙型肝炎E病毒的感染.这是一个沉重的负担.地方特有国家地方特有国家死亡率死亡率基于人口的估计.

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