一个审查的成本效益的植入前遗传测试对积血症的审查

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Updated: May 22, 2025

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

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Olamide Akin-Olugbade1, Tarun Jain2, Allison Komorowski3

  • 1Obstetrics and Gynecology Resident, Northwestern Memorial Hospital, Chicago, IL.

Obstetrical & gynecological survey
|March 13, 2025
PubMed
概括

对于某些接受体外受精 (IVF) 的患者,预植入基因测试 (PGT-A) 可能具有成本效益,但需要更多的研究. 目前关于PGT-A结果和患者体验的数据不完整.

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Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
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