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微RNA-155 rs767649的多态性与对植入周炎的易感性有关

Hao Fu¹, Xiangrong Li², Zeneng Xie³

¹School of Sanquan College of Xinxiang Medical University and dental technology, Xinxiang 453003, China.

Archives of oral biology

|March 13, 2025

概括

这种miR-155 rs767649多态性与周植入炎风险有关. TT基因型提高了miR-155的表达,增加了对这种牙疾病的易感性.

科学领域:

遗传学和分子生物学
口腔卫生和植入学植入学
生物标志物和疾病易感性

背景情况:

牙周植入物炎是植入牙植入物放置后的一个重大并发症.
微RNA-155 (miR-155) 与炎症过程有关.
基因变异,如单核酸多态 (SNP),可以影响基因表达和疾病风险.

研究的目的:

为了研究miR-155 rs767649多态化对miR-155表达水平的影响.
为了确定这种多态性和患上围植入炎的风险之间的关联.

主要方法:

分析了187名植入周炎患者和196名健康对照者的血清样本.
使用定量实时PCR (qRT-PCR) 来量化miR-155的表达.
使用TaqMan SNP测定,对miR-155 rs767649多态的基因类型进行了基因定型;预测了目标基因并对其进行了功能性注释.

主要成果:

与对照组相比,miR-155在周植入炎患者中显著上调 (P < 0.001).
携带rs767649 TT基因型的携带者表现出较高的miR-155血清水平 (P < 0.001) 和增加的周植入炎风险 (P = 0.016).
预计miR-155的下游标参与病毒感染和细胞分化等途径.

结论:

miR-155 rs767649的多态性与周植入炎易感性有关.
rs767649的TT基因型导致miR-155的表达增加,可能有助于周植入炎的发展.
这种遗传变异可能会影响相关的炎症信号通路周植入炎的发病因子.

关键词:

微型RNA-155是什么意思周植入体炎 (peri-implantitis) 是一种发生在周植入体内的疾病.多态性多态性多态性

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