高兴奋值与阻塞性睡眠呼吸暂停中的夜间胃食道逆流有关
Zhaoyan Feng1, Shuai Wu1, Mengmeng Wang2
1Division of Sleep Medicine, Peking University People's Hospital, Beijing, China.
Sleep medicine
|March 13, 2025
概括
高兴奋值 (ArTH) 与阻塞性睡眠呼吸暂停 (OSA) 患者的夜间胃食道逆流 (nGER) 有关. 这种关联显著,特别是在非肥胖个体中,影响了GGER的存在和症状频率.
科学领域:
- 睡眠医学 睡眠医学
- 胃肠病学 胃肠病学
- 肺部病理学 肺部病理学
背景情况:
- 夜间胃食道逆流 (nGER) 经常在阻塞性睡眠呼吸暂停 (OSA) 患者中观察到.
- 连接OSA和 nGER的潜在病理生理机制,特别是唤醒值 (ArTH) 的作用,仍然不完全理解.
- 了解这些联系对于全面的患者管理至关重要.
研究的目的:
- 为了确定OSA患者的临床特征,这些患者也经历了GGER.
- 研究激发值 (ArTH) 与OSA患者中GGER的存在之间的关联.
- 在非肥胖的OSA患者中探索ArTH和 nGER症状频率之间的关系.
主要方法:
- 一项涉及482名成年OSA患者的横截面研究,这些患者的诊断是通过多睡眠图 (PSG) 进行的.
- 由影响睡眠的每周典型症状 (烧心,酸性反) 定义的 nGER.
- 根据特定的PSG参数 (AHI,nadir SpO2,百分比下) 分类为高或低的ARTH;用于分析的多变量逻辑回归.
主要成果:
- 在OSA患者中,GGER症状的患病率为17.8%.
- 高ArTH,BMI≥28kg/m2,高爱普沃思睡眠度量 (ESS) 评分 (>16) 和年龄>60与增加的 nGER风险有关.
- 在非肥胖的OSA患者中,高ArTH独立预测了GGER存在 (OR=2.905) 和症状频率 (OR=2.856),即使在控制混因素之后.
结论:
- 高兴奋值是阻塞性睡眠呼吸暂停患者夜间胃食道逆流的独立危险因素.
- 对于非肥胖的OSA患者来说,高ArTH与 nGER症状的发生和频率都有显著的关联.
- 这些发现凸显了ArTH作为OSA和GER共患病的关键因素.
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