早期青春期的危险因素:系统审查和元分析
Ya Wang1, Hao Gou1, Junjun Guo1
1Department of Pediatrics, Hospital of Chengdu University of Traditional Chinese Medicine, No.39, Shierqiao Road, Jinniu District, Chengdu, Sichuan 610000, China.
Psychoneuroendocrinology
|March 13, 2025
概括
过早的青春期 (PP) 与更高的BMI,更早的母亲初潮和更短的母乳养时间有关. 早期诊断对于有风险的儿童至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖健康 生殖健康
- 公共卫生 公共卫生
背景情况:
- 早期青春期 (PP) 被定义为女孩在8岁和男孩在9岁之前开始青春期.
- 早期识别PP对于及时干预和管理至关重要.
- 了解风险因素可以提高诊断准确性和预防策略.
研究的目的:
- 系统地审查和元分析与早期青春期相关的风险因素.
- 在高风险人群中确定早期诊断和干预的关键指标.
主要方法:
- 在Cochrane图书馆,PubMed和Embase的综合文献搜索,截至2024年11月10日.
- 包括比较PP (暴露) 与无PP (控制) 参与者的研究.
- 随机效应模型用于计算几率比率 (OR) 和加权平均差异 (WMD) 的95%置信区间 (CI).
主要成果:
- 从最初识别的653篇论文中,包括了13项与15个队列的研究.
- 在PP和身体质量指数 (BMI),母亲初潮年龄和母乳养时间之间发现了显著的关联.
- 升高的雌激素 (E2),卵泡刺激激素 (FSH) 和黄素化激素 (LH) 水平与PP发生率有关.
结论:
- PP与增加的BMI,早期的母亲初潮和更短的母乳养时间密切相关.
- 包括E2,FSH和LH在内的荷尔蒙标志物与PP的存在有显著联系.
- 这些发现有助于识别有早期青春期风险的个体.
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