针对晚期结膜状细胞癌的免疫疗法:治疗失败
Amee D Azad1, Jia Jia Zhang1, Kevin S Emerick2
1Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, U.S.A.
Ophthalmic plastic and reconstructive surgery
|March 13, 2025
概括
系统性免疫检查点抑制剂 (ICI) 治疗在所有五名晚期结膜状细胞癌 (SCC) 患者中都显示出疾病进展. 在所有病例中都观察到低瘤突变负担,这表明它可能会影响治疗反应.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 晚期结膜状细胞癌 (SCC) 是一种罕见的恶性瘤.
- 系统性免疫检查点抑制剂 (ICI) 在各种癌症中表现有前途.
- 关于ICI对晚期结膜SCC的疗效的数据有限.
研究的目的:
- 为了评估晚期结膜SCC对全身ICI治疗的治疗反应.
- 为了确定影响ICI治疗结果的因素,在这个患者队列.
主要方法:
- 以ICI治疗的5名晚期结膜SCC患者的回顾性审查 (2015-2024年).
- 纳入标准:轨道侵入,不可切除或转移性疾病.
- 计算机断层扫描成像和瘤突变负担 (TMB) 的评估.
主要成果:
- 所有五名患者在ICI治疗中都出现了疾病进展.
- 三名患者在诊断后六个月内需要挖掘.
- 一名患者患上了转移性疾病,另一个患有内扩张.
- 所有患者呈现出低瘤突变负担.
结论:
- 与之前的报道相反,全身ICI疗法在所有研究中患有晚期结膜SCC的患者中显示出疾病进展.
- 低瘤突变负担可能与结膜SCC中的ICI反应不佳有关.
- 需要对更大的队列进行进一步的研究,以阐明ICI在结合性SCC管理中的作用.
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