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Phellinus pini的抗乳腺癌作用及其化学成分的表征

Jiajia Hu¹, Jiyuan Cao¹, Huixin Cheng¹

¹School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

|March 13, 2025

概括

菲林斯皮尼 (PPE) 的甲醇提取物抑制乳腺癌细胞活力,并恢复肠道菌群平衡. 个人防护品中的多被确定为其抗乳腺癌作用的关键活性化合物.

科学领域:

药理学药理学是指药理学的学科.
菌类学菌类学是指菌类学.
在瘤学瘤学.

背景情况:

菲林斯皮尼 (P. pini) 是一种具有已知的抗瘤潜力的传统药用宏观真菌.
针对乳腺癌的P. pini的特定活性化合物和机制在很大程度上仍未被阐明.

研究的目的:

为了研究Phellinus pini甲醇提取物 (PPE) 的抗乳腺癌作用.
确定负责抗乳腺癌活性的主要活性化学成分.

主要方法:

使用4T1乳腺癌细胞进行体外研究,以评估细胞活力,细胞亡,线粒体膜潜力和细胞周期.
对肠道微生物群和内源代谢物的分析.
使用Q ExactiveUPLC-MS/MS进行定量分析,以识别化学成分.

主要成果:

个人防护剂显著抑制了4T1细胞活力,诱导了亡,减少了线粒体膜潜力,并导致S相停止.
个人防护设备治疗恢复了由乳腺癌引起的肠道菌群不平衡,并调节了氨基酸水平.
聚醇被确定为介导PPE抗乳腺癌作用的主要化学成分.

结论:

菲林斯皮尼甲醇提取物通过多种机制表现出显著的抗乳腺癌特性.
聚是PPE中关键活性化合物,对其对抗乳腺癌的有效性负责.
这些发现支持P. pini作为乳腺癌治疗的治疗剂的潜力.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.乳腺癌是什么? 乳腺癌是什么化学成分化学成分肠道菌群是什么意思肠道菌群代谢学代谢学代谢学

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