怀孕期间的COVID-19疫苗接种和重大结构性出生缺陷
Stacey L Rowe1,2,3,4, Sheena G Sullivan5,6, Flor M Muñoz7
1School of Nursing and Health Professions, University of San Francisco, San Francisco, CA.
Pediatrics
|March 13, 2025
概括
怀孕早期的COVID-19疫苗接种是安全的,并没有增加重大出生缺陷的风险. 这一发现支持母婴COVID-19疫苗的安全性.
科学领域:
- 产科和妇科 产科和妇科
- 传染病流行病学 传染病流行病学
- 公共卫生 公共卫生
背景情况:
- 在怀孕早期 (≤20周怀孕) 接种COVID-19疫苗后,存在关于重大结构性出生缺陷的有限数据.
- 在怀孕期间评估疫苗安全性对于公共卫生建议至关重要.
研究的目的:
- 根据孕早期母亲的COVID-19疫苗接种状况,比较婴儿中主要结构性出生缺陷的患病率.
- 评估保险公司,SARS-CoV-2感染和联合使用疫苗对这种关联的影响.
- 为了进行Moderna和Pfizer-BioNTechCOVID-19疫苗之间出生缺陷流行率的对比比较.
主要方法:
- 一个基于索赔的队列研究包括怀孕的估计最后一个月经期在2021年8月15日至2021年12月24日之间.
- 使用双项回归与反向概率治疗加权计算了患病率.
- 根据保险公司,SARS-CoV-2感染和其他孕产妇疫苗分层分析.
主要成果:
- 在78,052例怀孕中,在接种疫苗 (156.4/10,000) 和未接种疫苗 (160.6/10,000) 个体之间,没有发现重大结构性出生缺陷的显著差异 (aPR,0.96;95% CI,0.81-1.13).
- 这些发现在不同的保险公司,SARS-CoV-2感染状况以及当其他孕产妇疫苗同时接种时保持一致.
- 在Moderna和Pfizer-BioNTech疫苗接种者之间没有观察到出生缺陷患病率的显著差异 (aPR,1.02;95% CI,0.77-1.37).
结论:
- 怀孕早期的COVID-19疫苗接种与重大结构性出生缺陷的患病率增加无关.
- 这些发现加强了COVID-19疫苗在怀孕早期使用的安全性.
- 这项研究支持目前对孕妇COVID-19疫苗接种的建议.
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