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复杂的金属相互作用网络和生物衰老在失脂症中介作用
Guohuan Yin1, Xingyu Chen2, Meiduo Zhao1
1Center for Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China; State Key Laboratory of Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
重金属混合物,包括,,,和,显著影响脂质不良. 这些金属之间的相互作用对脂质水平表现出协同作用和对抗作用,KDM.Accel介导.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生物化学 生物化学
背景情况:
- 暴露于金属混合物是导致失脂症的重要危险因素.
- 现有的研究将金属暴露与生物衰老和脂质失调联系起来,但金属相互作用和机制仍然不清楚.
研究的目的:
- 为了研究单一和组合金属暴露 (,,,,) 对失脂症的影响.
- 探索金属相互作用,它们的方向,以及KDM的调解作用.Accel在金属失脂症关系中的作用.
主要方法:
- 从2016年到2021年使用了一组重复测量队列 (403名参与者,1612次观察).
- 测量尿中的金属含量 (Cr,Cd,Pb,Mn) 和失脂症的生物标志物.
- 采用通用估计方程 (GEE),贝叶斯内核机器回归 (BKMR),协同指数和调解分析.
主要成果:
- 个人和联合暴露于Cr,Cd,Pb和Mn显著影响了脂质失调症.
- 多种金属相互作用对脂质结果 (例如,NHC) 具有协同和对抗作用.
- KDM.Accel调解了暴露与失脂症指标 (HDL-C,LDL-C,AC) 之间的关系.
结论:
- 混合重金属暴露及其相互作用与失脂症有关.
- 在金属失脂路径中,KDM.Accel起着至关重要的调解作用.
- 研究结果提供了对金属相互作用和KDM.Accel对失脂症的影响的见解.
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