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Updated: May 22, 2025

Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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PP2A适配蛋白IER5诱导MDM2的脱化和降解,从而稳定了p53

Taisei Nakada1, Mayuko Koga1, Hiroto Takeuchi1

  • 1Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 920-0942, Japan.

Cellular signalling
|March 13, 2025
PubMed
概括

适配蛋白IER5通过抑制瘤抑制剂p53 (蛋白53) 的无处不在,从而稳定瘤抑制剂p53. 这种调节涉及蛋白质酸酶PP2A/B55复合物和MDM2结合酶,维持核p53水平.

关键词:
在IER5中,IER5是IER5.MDM2DM2 在线播放在PP2A中,PP2A是PP2A.酸化是指酸化的方法.在Ubiquitination中使用.在 p53 里,p53 是一个 p53 号码.

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