暴露于挥发性有机化合物和自杀念头:来自美国基于人口的研究的见解
Huan He1, Zhonghua Sun1, Xin Chen2
1Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Nanjing 210011, China.
Journal of affective disorders
|March 13, 2025
概括
暴露于挥发性有机化合物 (VOC) 与自杀念头 (SI) 有关. 尿中的N-Acetyl-S-(2-cyanoethyl) -L-cysteine (CYMA) 被确定为与SI相关的关键代谢物,在炎症或氧化应激方面没有主要作用.
科学领域:
- 环境健康 环境健康
- 精神卫生流行病学 精神卫生流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 挥发性有机化合物 (VOC) 暴露越来越多地与心理健康问题有关.
- 挥发性有机物和自杀念头 (SI) 之间的具体联系需要进一步调查.
研究的目的:
- 调查VOC暴露与SI的流行之间的关联.
- 为了确定与SI相关的VOCs (mVOCs) 的特定尿路代谢物.
- 探索潜在的调解途径,如炎症和氧化应激.
主要方法:
- 来自国家健康和营养检查调查 (2005-2020) 的6966名参与者的分析.
- 使用弹性净回归识别关键的mVOCs.
- 探索使用多变量逻辑回归和受限制立方线模型的关联.
- 使用环境风险评分和权重量子总和模型对mVOC混合物的评估.
- 对炎症和氧化应激通路的调解分析.
主要成果:
- 在mVOC混合物和SI患病率之间发现了显著的积极关联.
- 尿中的N-Acetyl-S-(2-cyanoethyl) -L-cysteine (CYMA) 是与SI相关的最持续显著的mVOC.
- 调解分析表明,炎症和氧化应激不是主要的机制.
结论:
- 这项研究提供了第一个流行病学证据,将mVOCs暴露与SI联系起来.
- CYMA被确定为与SI相关的关键泌尿代谢物.
- 暴露于mVOCs和SI之间的关联似乎不是由炎症或氧化应激介导的.
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