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在月经前综合征中,thalamic亚区域的功能连接性发生变化

Ruijing Sun¹, YinQi Lai¹, Qingping Zhang¹

¹The People's Hospital of Guangxi Zhuang Autonomous Region, Department of Radiology, China.

Journal of affective disorders

|March 13, 2025

概括

月经前综合征 (PMS) 与thalamic亚区域的大脑连接的改变有关,特别是涉及中额头和岛屿. 炎症似乎在这些变化中起着关键作用,与症状严重程度相关.

科学领域:

神经成像是一种神经成像.
神经科学是一个神经科学.
精神病学是一个精神病学.

背景情况:

月经前综合征 (PMS) 显著影响女性的生活质量.
在PMS症状的神经生物学基础需要进一步的研究.
胸膜子区域对于处理情绪和感官信息至关重要.

研究的目的:

调查月经前综合征 (PMS) 症状与体亚区域的变化之间的关系.
探索与PMS相关的功能和结构性大脑变化.
为了确定潜在的神经成像生物标志物用于PMS严重程度.

主要方法:

招募了71名PMS患者和81名健康对照 (HC).
使用每日记录问题的严重程度 (DRSP) 尺度评估症状严重程度.
从MRI扫描中利用了静止状态功能连接 (rsFC) 和灰质体积 (GMV).
分析了对细胞因子和激素水平的外周血液样本.

主要成果:

与HCs相比,PMS患者在中间前额回环 (MFG) 和左侧乳头核之间,以及在insula和左侧后部 (LP) 核之间表现出改变的rsFC.
DRSP得分与rsFC相关,并与TNF-α水平积极相关.
rsFC显示与炎症性细胞因子的相关性,表明炎症成分.

结论:

thalamic亚区域的功能连接性改变与PMS症状严重程度 (DRSP得分) 有关.
炎症显著影响着体神经回路,特别是体-MFG-岛屿网络.
这些发现强调了神经炎症在PMS病理生理学中的作用.

关键词:

功能连接性的功能连接性.功能性磁共振成像技术功能性磁共振成像技术在月经前综合征.泰拉姆斯泰拉姆斯泰拉姆斯

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