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Updated: Apr 13, 2026

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一个新型的受控释放系统Au-CuONP/P(MMAcoMAA) /奇托桑纳米复合材料:合成,表征,抗菌活性和在分子对接

Ecem Isiksel¹, Azade Attar², Lalehan Ozalp³

¹Yildiz Technical University, Faculty of Science and Letters, Department of Chemistry, Davutpasa Campus, 34220 Istanbul, Turkey.

International journal of biological macromolecules

|March 13, 2025

概括

绿色合成的双金属金-铜氧化物 (Au-CuO) 纳米粒子被用于创建用于药物输送的新型纳米复合材料. 这些Au-CuO纳米复合材料具有显著的抗菌和抗真菌特性,以及可控释放能力.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
绿色化学绿色化学

背景情况:

开发具有成本效益和环保的纳米材料用于药物输送至关重要.
双金属纳米颗粒为抗微生物应用提供了独特的特性.
植物提取物为纳米粒子合成提供了一个可持续的来源.

研究的目的:

使用绿色合成双金属金铜氧化物 (Au-CuO) 纳米粒子合成抗菌纳米复合材料.
评估这些纳米复合材料的抗菌活性和受控释放潜力.
研究Au-CuO纳米颗粒与微生物酶的结合机制.

主要方法:

使用植物提取物 (Cotoneaster,Laurus nobilis,Salvia officinalis) 的Au-CuO纳米颗粒的绿色合成.
纳米复合材料的制造与奇托/纳米奇托和P(MMAcoMAA).
使用FT-IR,XRD,SEM,UV-Vis,DLS和抗菌分析进行表征.
使用牛血清白蛋白 (BSA) 模型和分子对接模拟的受控释放研究.

主要成果:

Au-CuO纳米粒子和纳米复合材料已成功合成和表征.
纳米复合材料显示出对大肠杆菌和黄金色杆菌的显著抗菌活性,以及对黑色杆菌的抗真菌活性.
在7天内观察到BSA的受控释放,基托基纳米复合材料的释放百分比很高.
分子对接表明Au-CuO NPs与微生物酶的结合 afinities,这表明了潜在的作用机制.

结论:

开发了一种新的环保纳米复合材料,具有强大的抗微生物特性和受控释放能力.
合成的Au-CuO纳米复合材料显示出在药物输送和抗菌治疗中的应用的前景.
该研究强调了绿色合成双金属纳米粒子在先进材料开发中的潜力.

关键词:

具有抗菌活性,具有抗菌活性.它具有抗真菌活性,具有抗真菌活性.在Au-CuO纳米粒子.基托桑是一种酸盐.有控制的药物释放.

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