哺乳与自身免疫性疾病风险之间的关联:系统性审查和元分析
Wen-Jie Li1, Yue-Can Gao2, Xiao Hu2
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, People's Republic of China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, 81 Meishan Road, Hefei 230032, Anhui, People's Republic of China.
哺乳可以保护自身免疫性疾病,包括类风湿性关节炎,多发性硬化和1型糖尿病. 这种益处在母乳养持续时间为四个月或更长时间时得到了增强.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 儿科 儿科 儿科
背景情况:
- 关于母乳养对自身免疫性疾病风险的影响存在不一致的发现.
- 自身免疫性疾病对全球健康构成重大负担.
研究的目的:
- 系统地审查和元分析母乳养与发展自身免疫性疾病的风险之间的关联.
- 研究母乳养时间对自身免疫性疾病风险的影响.
主要方法:
- 在六个主要数据库中进行了系统的文献搜索.
- 包括专注于母乳养和类风湿性关节炎,全身性红斑狼,性结肠炎,克罗恩病,多发性硬化和1型糖尿病的研究.
- 随机效应元分析被用来汇集效应大小,研究质量使用纽卡斯尔-太华尺度进行评估.
主要成果:
- 对40项研究的元分析显示,母乳养与减少自身免疫性疾病风险 (OR=0.80) 之间存在显著的保护性关联.
- 对类风湿性关节炎 (OR=0.66),多发性硬化症 (OR=0.78) 和1型糖尿病 (OR=0.80) 观察到特殊的保护作用.
- 哺乳期至少4个月显示出更明显的保护作用 (OR=0.81).
结论:
- 母乳养对自身免疫性疾病具有整体的保护作用.
- 对于类风湿性关节炎,多发性硬化和1型糖尿病而言,已注意到显著的保护作用.
- 促进母乳养,特别是持续四个月或更长时间的母乳养,对于婴儿健康和疾病预防至关重要.
更多相关视频
13:00Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
Published on: July 31, 2021
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
相关概念视频
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Psychoneuroimmunology: Diabetes and Cancer
What is the Immune System?
