Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Language and Cognition01:27

Language and Cognition

303
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
303
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

121
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
121
Long-term Potentiation01:35

Long-term Potentiation

54.6K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
54.6K
Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

702
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
702
Long-term Depression01:03

Long-term Depression

2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.5K
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

2.1K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep...
2.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

An update in the MRI features, classification, and associated brain abnormalities in hypothalamic hamartomas.

BJR open·2026
Same author

Reconstruction of MRI from undersampled k-spaces of double-contrast volume acquisitions using deep neural networks.

Magnetic resonance imaging·2026
Same author

Sex-related structural alterations across common epilepsies: a worldwide ENIGMA study.

bioRxiv : the preprint server for biology·2026
Same author

Editorial: Cognitive enhancement by brain stimulation techniques.

Frontiers in human neuroscience·2026
Same author

Abnormal functional connectivity patterns in temporal lobe epilepsy-An international ENIGMA-epilepsy study.

Epilepsia open·2026
Same author

Altered resting-state functional connectivity in delusional patients with schizophrenia or schizoaffective disorder: An fMRI study using threshold-free cluster-enhancement.

Psychiatry research. Neuroimaging·2026

相关实验视频

Updated: May 22, 2025

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

17.9K

时间叶中的语言和记忆网络变化:功能和结构连接性研究

Alireza Fallahi1, Mohammad-Reza Nazem-Zadeh1, Narges Hosseini-Tabatabaei1

  • 1From the Department of Biomedical Engineering (Alireza.Fallahi.), Hamedan University of Technology, Hamedan, Iran; Department of Neurosciences, Addiction Studies & Neuroimaging (Mohammad-Reza Nazem-Zadeh), School of Advanced Technologies in Medicine, Medical School (Narges Hosseini-Tabatabaei), Tehran University of Medical Sciences, Tehran, Iran; Isfahan Neuroscience Research Center (Jafar Mehvari Habibabadi), Isfahan University of Medical Sciences, Isfahan, Iran; Pars Advanced Medical Research Center (Seyed-Sohrab Hashemi-Fesharaki), Pars Hospital, Tehran, Iran; CIPCE, School of Electrical and Computer Engineering (Hamid Soltanian-Zadeh), Faculty of Engineering, University of Tehran, Tehran, Iran; Department of Neurosciences (Mohammad-Reza Nazem-Zadeh), Monash University, Melbourne, VIC, Australia; Medical Image Analysis Lab., Departments of Radiology and Research Administration (Hamid Soltanian-Zadeh), Henry Ford Health System, Detroit, MI, USA.

AJNR. American journal of neuroradiology
|March 13, 2025
PubMed
概括

这项研究揭示了叶 (TLE) 患者的大脑连接的改变,在手术前显示功能性超连接性,在手术后显示低连接性. 机器学习使用这些连接模式准确地识别了TLE横向化.

更多相关视频

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.1K
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

8.3K

相关实验视频

Last Updated: May 22, 2025

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

17.9K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.1K
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

8.3K

科学领域:

  • 神经科学是一个神经科学.
  • 医疗成像医学成像
  • 计算神经科学是一种神经科学.

背景情况:

  • 时间叶 (TLE) 涉及到大脑网络的复杂变化.
  • 了解TLE中的语言记忆网络 (LMN) 对诊断和治疗至关重要.
  • 在TLE中术前和术后网络变化需要详细调查.

研究的目的:

  • 评估TLE中LMN功能和结构连接的术前和术后变化.
  • 利用图形理论和机器学习来实现自动的TLE横向化.
  • 探索TLE患者大脑连接和认知功能之间的关系.

主要方法:

  • 休息状态fMRI和扩散张力成像 (DTI) 数据来自35名TLE患者和20名健康对照 (HCs).
  • 在手术前和手术后的LMN内计算功能和结构连接.
  • 应用图形理论,特征选择和机器学习算法 (SVM,天真贝叶斯,逻辑回归) 进行分类和横向化.

主要成果:

  • 在外科手术前,TLE患者表现出功能性增加和结构性连接性降低,在手术后逆转.
  • 机器学习模型,特别是带有遗传算法的SVM,在分类TLE亚型 (LTLE与RTLE) 和区分TLE与HC时实现了高精度 (高达97%).
  • 关键的变化区域包括近海马 (LTLE) 和部区域 (RTLE);结构变化源于双边尾和左侧语言区域.
  • 在连接特征和与记忆相关的认知得分之间发现了显著的相关性.

结论:

  • TLE的特点是LMN内的动态功能和结构连接性改变,具有明显的手术前和后模式.
  • 机器学习方法显示出对客观的TLE诊断和横向化的巨大潜力.
  • 这项研究强调了先进的神经成像和计算方法在理解TLE病理生理学的有用性.