在看似经典的帕金森病中重新考虑大脑MRI:每位患者一次性结构成像?
Roderick P P W M Maas1, Huiberdina L Koek2, Frederick J A Meijer3
1Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands roderick.maas@radboudumc.nl.
Practical neurology
|March 13, 2025
概括
专家临床诊断是帕金森病 (PD) 的关键. 然而,这项研究表明,对缺乏明显的非运动症状的患者来说,脑部MRI可能是有益的,可能会揭示潜在的潜在原因.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
背景情况:
- 专家临床意见,包括病史和神经学检查,是诊断帕金森病 (PD) 的黄金标准.
- 神经成像通常被认为是不必要的,对于患者呈现特征性PD表型.
研究的目的:
- 探索脑部MRI在患有显然是经典运动帕金森病的患者中的潜在指示.
- 建议修订的指导方针,考虑在特定的PD患者群体中进行神经成像.
主要方法:
- 对两名患有帕金森病的患者的案例研究审查.
- 对临床表现和神经成像发现的分析.
- 关于帕金森病诊断标准的文献综述.
主要成果:
- 两例病例通过MRI揭示了帕金森症状的意想不到的潜在原因,尽管初步的临床评估表明不需要成像.
- 两位患者都没有表现出明确的非运动性症状,突出显示了潜在的诊断挑战.
结论:
- 经典运动性PD患者缺乏明确的非运动性症状应被视为一个重要的指标,可能需要通过脑MRI进行进一步的调查.
- 在选择的帕金森病患者中降低脑部扫描的门,可能会发现可治疗的疾病并完善诊断.
更多相关视频
09:06Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
Published on: June 9, 2018
12.1K
07:26Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
Published on: September 26, 2019
7.7K
相关概念视频
01:15Parkinson's Disease: Overview
410
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
410
01:37Neural Regulation
39.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.0K
01:24Parkinson's Disease: Treatment
174
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
174