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Updated: Jul 2, 2026

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心脏 Amyloidosis:内肌心细胞活检的作用

Veronica Musetti1, Francesco Greco2, Alberto Aimo1

  • 1Health Science Interdisciplinary Center, Scuola Superiore Sant'Anna, Pisa, Italy; Fondazione Toscana Gabriele Monasterio, Pisa, Italy.

Heart failure clinics
|March 13, 2025
PubMed
概括

诊断心脏氨基粉症对于治疗至关重要. 最近成像技术的进步有助于进行非侵入性检测,特别是对甲氨化症 (ATTR) 的检测. 心内膜活检 (EMB) 证实了诊断,并在需要时帮助确定粉样蛋白的类型.

关键词:
在AL氨基粉症症.在ATTR的氨基粉症.心脏氨基粉症症的心脏粉症内心肌组织活检内心肌组织活检历史学 历史学 历史学免疫组织化学 免疫组织化学蛋白质组学是指蛋白质组学.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...