穿透细胞的循环和富含硫化物是细胞内向的特权分子支架
Sónia Troeira Henriques1,2, Nicole Lawrence2,3, Meng-Wei Kan2,3
1School of Biomedical Sciences, Queensland University of Technology, Translational Research Institute, Brisbane, QLD 4102, Australia.
Biochemistry
|March 13, 2025
概括
来自自然界的循环和富含二硫化物显示出增强的稳定性和细胞透. 工程和人工智能设计方法进一步改进了针对细胞内治疗的这些特性.
科学领域:
- 生物化学 生化学
- 分子生物学分子生物学
- 药物发现 药物发现 药物发现
背景情况:
- 与线性相比,循环和具有二硫化键的具有更高的稳定性.
- 来自各种生物体的某些循环和富含二硫化物,显示出细胞透能力.
- 这些因其固有的稳定性和细胞进入特性而具有作为治疗剂的潜力.
研究的目的:
- 审查精选的循环和二硫化物丰富的的结构和生物物理特性.
- 探索增强稳定性和细胞吸收的工程策略.
- 讨论这些在向细胞内治疗标中的应用.
主要方法:
- 自然循环和富含二硫化物的结构和生物物理特征.
- 体工程用于提高稳定性,细胞吸收和点特异性.
- 机器学习和人工智能 (AI) 在 de novo 体设计中的审查.
- 对体透和口服生物可用性的类药物合物的分析.
主要成果:
- 精选的循环和富含二硫化物具有有利的结构和生物物理特征.
- 工程方法可以显著提高稳定性和细胞传递.
- 由人工智能驱动的de novo设计正在加速穿透膜的的开发.
- 设计的宏环和-药物合物显示出口服生物可用性的前景.
结论:
- 自然启发的循环和富含二硫化物是细胞内治疗的有希望的支架.
- 通过工程和计算设计来定制的特性,提高了它们的治疗潜力.
- 先进的设计方法,包括人工智能,正在彻底改变细胞透的开发.
- 这些具有治疗细胞内疾病的潜力,包括癌症和感染.
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