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Updated: May 22, 2025

Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation
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来自肝脏的Neuregulin1α刺激胰腺补偿性β细胞增生,在胰岛素耐药性方面发挥作用

Takatomo Arai1, Eriko Hayashi1, Sumie Maeda1

  • 1Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.

Nature communications
|March 14, 2025
PubMed
概括

肝脏蛋白Neuregulin1α驱动胰腺β细胞扩张,以满足2型糖尿病患者的胰岛素需求. 这种肝因通过增加功能性β细胞质量来增强葡萄糖控制.

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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