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Updated: May 22, 2025

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以FAN1为媒介的转化合成和以POLQ/HELQ为媒介的末端连接产生跨链引发的跨链突变

Jip Verschuren1, Robin van Schendel1, Ivo van Bostelen1

  • 1Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

Nature communications
|March 14, 2025
PubMed
概括

DNA 链间交联 (ICL) 修复可以导致突变. 这项研究揭示了C. elegans中两个主要的ICL修复途径:一个导致单核酸变化,另一个导致删除,突出了对遗传完整性的影响.

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