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相关概念视频

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

375
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Endoscopic Procedures V: ERCP01:26

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Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
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Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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原发性硬化性胆管炎的发生.

Michael P Manns1, Annika Bergquist2, Tom H Karlsen3,4

  • 1Hannover Medical School (MHH) and Centre for Individualised Infection Medicine (CiiM), Hannover, Germany. manns.michael@mh-hannover.de.

Nature reviews. Disease primers
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PubMed
概括
此摘要是机器生成的。

初级硬化性胆道炎 (PSC) 是一种罕见的自身免疫性肝病,导致胆道炎症和纤维化. 目前的治疗方法提供了有限的生存益处,突出了对新型疗法和改善生活质量的需求.

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科学领域:

  • 肝病学 肝病学是一种肝病学.
  • 自免疫性疾病 自免疫性疾病
  • 胃肠病学 胃肠病学

背景情况:

  • 初级硬化性胆道炎 (PSC) 是一种慢性,渐进的自身免疫性肝病,其特征是胆道炎症和纤维化.
  • 它经常与炎症性肠道疾病 (IBD) 一起发生,影响所有种族和年龄,主要是年轻男性.
  • 病因学和病理生理学在很大程度上是未知的,尽管它的自身免疫基础.

研究的目的:

  • 总结有关PSC的当前知识,包括其诊断,管理和相关风险.
  • 确定PSC治疗和患者护理中未得到满足的医疗需求.
  • 审查新兴的治疗策略及其对生存和生活质量的潜在影响.

主要方法:

  • 对PSC流行病学,病原,临床表现和治疗现有文献的审查.
  • 诊断方式的分析,包括磁共振成像 (MRI) 和内镜干预.
  • 评估当前和研究中的治疗方法,包括医疗,内镜和手术选择.

主要成果:

  • PSC导致胆道狭窄,细菌性胆道炎,肝脏衰竭,并且经常需要肝脏移植.
  • Ursodeoxycholic 酸通常用于胆固醇症,但不会改善无移植生存率.
  • 针对酸通路,炎症和肠道微生物群的新型疗法正在进行重大研究.

结论:

  • PSC是一种复杂的自身免疫性肝病,具有显著的发病率和死亡率,缺乏经批准的医疗疗法来改善存活率.
  • 通过MRI进行准确的诊断和明智的内镜干预是至关重要的.
  • 对新型治疗方法和微生物组操纵的持续研究为改善患者治疗结果提供了希望.