早期的肠道微生物组与里约出生队列中的行为障碍有关
Nathalia Ferrazzo Naspolini1,2, Ana Paula Natividade3, Carmen Ildes Froes Asmus4
1Oswaldo Cruz Foundation, National School of Public Health Sergio Arouca, Rio de Janeiro, Brazil. nfnaspolini@gmail.com.
Scientific reports
|March 14, 2025
概括
婴儿出生时的肠道微生物组与神经行为发育有关. 特定的细菌在麦科尼 (婴儿) 中.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
背景情况:
- 早期的肠道微生物组组成会影响宿主发育,包括大脑功能.
- 婴儿肠道中的创始细菌启动微生物继承,影响神经发育结果.
研究的目的:
- 为了研究微生物组与婴儿的神经行为结果之间的关联.
- 为了确定与发展里程碑相关的麦中特定的微生物模式.
主要方法:
- 在样本中调查了16S rRNA基因,以分析早期的肠道微生物组.
- 在六个月时使用丹佛发育查测试II (DDST-II) 评估婴儿的神经行为.
- 分析了微生物多样性与特定行为领域之间的关联,并调整了混因素.
主要成果:
- 个人-社会领域神经行为显示,在菌的β多样性和减少的α多样性中存在显著差异.
- 改变的神经行为与特定细菌家族 (Ruminococcaceae,Christensenellaceae) 和属的过度代表有关.
- 预测的功能基因在神经行为改变的婴儿中较少.
结论:
- 微生物组与早期的神经行为结果有关,特别是在个人-社会领域.
- 初始肠道微生物群中的特定细菌种群和预测的功能可能会影响婴儿的发育.
- 需要对不同新生儿群体进行进一步的研究来证实这些发现.
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