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益生菌Bifidobacterium bifidum菌株去除MUC13和增加肠道上皮质屏障的功能

Celia Segui-Perez¹, Liane Z X Huang¹, Fernanda L Paganelli²

¹Department of Biomolecular Health Sciences, Division Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Scientific reports

|March 14, 2025

概括

某些Bifidobacterium bifidum菌株通过降低MUC13.5来增强肠道屏障功能. 这些特定的益生菌菌株表现出独特的特性,有助于改善肠道健康和完整性.

科学领域:

微生物学微生物学
胃肠病学胃肠病学
免疫学免疫学免疫学

背景情况:

众所周知,益生菌细菌,特别是Bifidobacteria,可以改善肠道健康,但它们的分子机制尚不清楚.
双杆菌是关键的肠道物种,但它们在成年人中的数量很低.
殖民需要降解宿主碳水化合物,例如与粘素相关的寡糖.

研究的目的:

选益生菌株以检测它们调节MUC13和增强肠道屏障功能的能力.
研究Bifidobacterium菌株影响肠道屏障的分子机制.
为了确定具有有益益生菌性质的特定Bifidobacterium菌株.

主要方法:

对MUC13调节的益生菌细菌菌株的查.
Bifidobacterium bifidum菌株的特征,包括附着性, sialidase活性和粘液透.
对表皮屏障完整性的评估.

主要成果:

一种特定的Bifidobacterium bifidum菌株独特地降解了MUC13 O-糖基化细胞外域.
两种益生菌B. bifidum菌株 (W23和W28) 显示出强大的顶端粘附性,高化酶活性和粘液层透.
这些菌株显著增强了上皮质屏障的完整性.

结论:

益生菌作用是菌株特异性的,某些B. bifidum菌株表现出对肠道健康有益的独特特性.
由B. bifidum降解MUC13有助于增强肠道屏障功能.
这些发现强调了菌株选择对于有效的益生菌干预措施的重要性.

关键词:

这种细菌是Bifidobacterium bifidum.牛奶植物植物菌植物植物 (Lactiplantibacillus plantarum) 是一种植物.乳酸菌植物植物 (Lactobacillus plantarum) 是一种植物菌.肠道屏障的功能肠道屏障的功能在MUC13中,MUC13是MUC13中的一个.神经氨基酸酶是一种神经氨基酸酶.益生菌益生菌益生菌酸是酸中的一种.溶性粘液层是一种可溶性粘液层.紧密的结口是紧密的结口.

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