解开各种风险因素和肺癌死亡率趋势的影响
Xiu Wu1, Jinting Zhang2, Yilin Yoshida3
1School of Medicine, Tulane University, New Orleans, LA, 70112, USA. xwu17@tulane.edu.
Scientific reports
|March 14, 2025
概括
肺癌死亡率受到除PM2.5污染之外的其他因素的影响,包括职业暴露,生活方式选择和健康状况. 预防策略必须解决这些不同的风险因素,特别是在肺癌发病率上升的国家.
科学领域:
- 在瘤学瘤学.
- 环境健康 环境健康
- 流行病学 流行病学
背景情况:
- 肺癌是全球癌症死亡的主要原因之一.
- 各种风险因素对肺癌死亡率 (LCM),特别是非吸烟者的具体影响需要进一步阐明.
研究的目的:
- 量化各种风险因素对肺癌死亡率 (LCM) 的影响.
- 为了确定LCM利率的全球趋势.
- 通过突出关键风险因素,为肺癌预防策略提供信息.
主要方法:
- 利用随机森林树 (RFT) 和梯度增强回归 (GBR) 来识别主要的LCM风险因素.
- 采用部分和皮尔森相关性来过204个国家 (2005-2019) 的重大风险因素.
- 应用多重连接点回归来分析LCM利率趋势.
主要成果:
- 诸如职业暴露,吸烟,,二氧化,石棉暴露,高血压,二手烟,儿童丧和酒精使用等因素对LCM的影响比PM2.5.5.更大.
- 在142个国家 (如中国,印度) 中,LCM的发病率正在上升,在38个国家 (如丹麦,挪威) 中正在下降,在24个国家 (如澳大利亚) 中保持稳定.
结论:
- 预防肺癌必须考虑广泛的风险因素,包括职业暴露,生活方式和健康状况,而不仅仅是PM2.5.5.
- 针对性预防工作对于正在经历越来越多的LCM趋势的国家至关重要,这些趋势包括诸如石暴露,高血压和酒精使用等因素.
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