与损伤相关的阿克罗莱因暴露:一个横截面研究
Jianchao Ma1, Youqi Lu1, Yang Cai2
1Department of Orthopedics, Minzu Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530001, People's Republic of China.
Scientific reports
|March 14, 2025
概括
这项研究表明,暴露于有毒物质阿克罗莱因 (Acr) 与慢性病 (CKD) 风险增加和估计膜过率 (eGFR) 降低有关. 暴露于阿克罗莱因与严重的损伤有关.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 毒理学 毒理学 毒理学
背景情况:
- 蛋白 (Acr) 是一种常见的挥发性有毒物质,通过脏分泌.
- 没有先前的研究专门研究了ACR对功能的影响.
- 了解Acr的影响对于公共卫生和临床脏病学至关重要.
研究的目的:
- 为了研究尿液中阿克罗莱因 (Acr) 度与脏损伤之间的关系.
- 评估Acr暴露与慢性病 (CKD) 风险和估计的淋巴球透率 (eGFR) 之间的关联.
主要方法:
- 这是一项横截面研究,利用了2011-2018年国家健康和营养检查调查 (NHANES) 的4951名参与者的数据.
- 测量了尿中的Acr度,eGFR和尿中的白蛋白与肌素比率 (UACR).
- 用多变量回归分析,平滑曲线拟合,子组分析和灵敏度分析来评估Acr与CKD和eGFR的关联.
主要成果:
- 尿液中的Acr度与CKD风险增加和eGFR降低有显著关联.
- 每个单位的log2Acr增加都与6%更高的CKD风险 (OR=1.06) 和0.54mL/min/1.73m2 eGFR的减少有关.
- 与最低四分位数 (Q1) 相比,Acr最高四分位数 (Q4) 的参与者表现出29%更高的CKD风险和1.90 mL/min/1.73 m2更低的eGFR.
结论:
- 暴露于阿克罗莱因与损伤有显著的关联,包括增加CKD风险和功能受损.
- 这项研究提供了新的证据,将挥发性有毒物质阿克罗莱因与功能下降联系起来.
- 这些发现突出了阿克罗莱因的潜在毒性作用,并要求进一步调查其在病病原发生中的作用.
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