多维生素补充剂及其对代谢功能障碍相关的脂肪性肝病的影响
Tom Ryu1, Seung Yun Chae2, Jaejun Lee3
1Department of Internal Medicine, Institute for Digestive Research, Digestive Disease Center, Soonchunhyang University College of Medicine, Seoul, 04401, Republic of Korea.
Scientific reports
|March 14, 2025
概括
多种维生素的使用可能会降低与代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的死亡率和疾病风险. 虽然不降低肝脏特异性死亡率,但多种维生素显示出对所有原因死亡率,心血管疾病和慢性病的保护作用.
科学领域:
- 临床营养学 临床营养学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题,治疗选择有限.
- 多种维生素是常见的补充剂,具有潜在的抗炎和抗氧化作用,但它们对MASLD结果的影响尚未确立.
研究的目的:
- 调查多维生素消费与有或没有MASLD的个体的主要健康结果之间的关联.
- 评估复合维生素对所有原因死亡率,肝脏相关死亡率,心血管疾病 (CVD) 和慢性病 (CKD) 在MASLD人群中的影响.
主要方法:
- 利用英国生物库数据,随访时间中位数为7年.
- 使用治疗权重的逆概率 (IPTW) 来控制混因素.
- 在MASLD和非MASLD队列中分析了多维生素使用与死亡率,心血管疾病和CKD之间的关联.
主要成果:
- 在IPTW调整之前和之后,多维生素使用者与MASLD的死亡风险显著降低,无论是IPTW调整之前还是IPTW调整后 (HR:0.94,P=0.037).
- 服用多种维生素的MASLD患者也显示心血管疾病 (HR:0.72,P<0.001) 和CKD (HR:0.73,P<0.001) 的风险较低.
- 在使用多种维生素和减少与肝脏相关的死亡率或肝硬化发病率之间没有发现显著的关联.
结论:
- 复合维生素在代谢功能障碍的个体中,可能提供超出肝脏健康的保护性益处.
- 研究结果表明,在MASLD人群中,复合维生素可能有更广泛的健康益处.
- 需要进一步的研究来阐明多种维生素在肝脏相关结果中的特定作用.
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