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增加支气管肺功能障碍,以及极度早产婴儿的死亡率降低
Ga Won Jeon1, Minkyung Oh2, Yun Sil Chang3,4
1Department of Pediatrics, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.
Scientific reports
|March 14, 2025
概括
尽管新生儿护理取得了进展,但极早产婴儿 (EPI) 面临着支气管肺功能失调 (BPD) 的增长率. 这一趋势表明EPI中生存率和BPD发病率之间的权衡,这是由更长的呼吸器支持驱动的.
科学领域:
- 新生儿科学 新生儿科学
- 儿科肺病学 儿科肺病学
- 关键护理医学 关键护理医学
背景情况:
- 新生儿重症监护改善了极度早产婴儿 (EPI) 的存活率.
- 然而,在这个人群中,支气管肺功能障碍 (BPD) 的发病率仍然很高或正在增加.
- 了解BPD和死亡率的趋势对于优化EPI护理至关重要.
研究的目的:
- 检查韩国EPI中死亡率,BPD和BPD或死亡率的综合结果的趋势.
- 调查呼吸系统支持策略与这些结果之间的关系.
主要方法:
- 来自韩国新生儿网络 (2014-2021) 的EPI (妊娠年龄23-27周) 全国队列的分析.
- 包括4,450名幸存者进行结果评估.
- 在研究期间比较BPD发病率,死亡率和复合结果.
主要成果:
- 幸存者中BPD发生率从51.2%增加到62.7% (P < 0.001).
- 死亡率显著下降,从28.3%降至19.5% (P < 0.001).
- 脊椎障碍或死亡率的综合结果从63.6%增加到66.9% (P = 0.006),与整体呼吸系统支持的持续时间增加有关.
结论:
- 尽管死亡率降低,但韩国EPI中BPD的发病率和BPD或死亡率的复合结果增加了.
- 长时间的呼吸系统支持,特别是非侵入性通风,可能会导致BPD率的上升.
- 在极度早产婴儿中,改善生存率和增加BPD发病率之间似乎存在一种权衡.
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