基于NHANES 2011-2018的饮食蛋白质摄入量和骨矿物质密度之间的关联
Xingxing Chen1, Yonghua Fu2, Zhongxin Zhu3
1Clinical Research Center, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, No. 199 South Shixin Road, Hangzhou, 311200, Zhejiang, People's Republic of China.
Scientific reports
|March 14, 2025
概括
更高的饮食蛋白质摄入量与更好的骨矿物质密度 (BMD) 有关. 这种关联因性别和种族而异,观察到最佳骨健康益处的特定摄入门.
科学领域:
- 营养科学 营养科学
- 骨健康研究 骨健康研究
- 公共卫生 公共卫生
背景情况:
- 关于饮食中的蛋白质对骨矿物质密度 (BMD) 的影响,存在相互矛盾的证据.
- 了解这种关系对于骨健康管理和营养指南至关重要.
- 之前的研究还没有完全阐明人口特异性关联.
研究的目的:
- 通过使用大型,具有全国代表性的数据集,调查饮食中的蛋白质摄入量和骨质量之间的关联.
- 为了确定潜在的值效应和变化,在这个关系跨人口亚组.
- 解决现有的争议,并为临床实践提供基于证据的见解.
主要方法:
- 这是一项横截面研究,利用了2011-2018年国家健康和营养检查调查 (NHANES) 中16775名参与者的数据.
- 通过使用国家癌症研究所 (NCI) 方法进行24小时回忆评估的饮食蛋白质摄入量.
- 通过双能X射线吸收计测量全身BMD,使用加权回归和通用添加模型对共变量进行调整分析.
主要成果:
- 在饮食中的蛋白质摄入量和BMD之间观察到显著的积极关联 (每克蛋白质增加0.0003 g/cm2).
- 小组分析显示,女性和墨西哥裔美国人之间存在显著的正相关性.
- 在女性 (60.70克/天) 和非西班牙裔白人 (135.53克/天) 中观察到和值效应.
结论:
- 饮食中的蛋白质摄入量与BMD有积极的关联,但这种关系是复杂的和非线性的.
- 值效应表明,超出某些摄入量水平,在特定人群中,正相关性会减少.
- 研究结果支持个性化的饮食建议,以优化骨健康,并为临床干预提供信息.
相关概念视频
Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
Proteins: Dietary Sources and Requirements
339
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
339
Role of Vitamins in Maintaining Bone Health
3.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.1K
Essential Minerals for Bone Health
3.7K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
3.7K
Hormones and Bone Tissue
2.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.5K
Overview of Protein Metabolism
646
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
646


