对抗癌症治疗次要的Vogt-Koyanagi-Harada类疾病:一个多中心病例系列
Cristhian A Urzua1,2,3, Alvaro Olate-Perez4,5, Rodrigo Anguita6
1Laboratory of Ocular and Systemic Autoimmune Diseases, Faculty of Medicine, University of Chile, Santiago, Chile. cristhian.urzua@uchile.cl.
Eye (London, England)
|March 14, 2025
概括
沃格特-科亚纳吉-哈拉达 (VKH) 样疾病可能会在新的抗癌治疗中发生. 高剂量的皮质类固醇是主要治疗方法,耐火病例的免疫调节疗法.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 新兴的新型抗癌疗法与独特的免疫相关不良事件有关.
- 沃格特-科亚纳吉-哈拉达病 (VKH) 是一种罕见的自身免疫性疾病,会影响阴道管.
研究的目的:
- 为了描述Vogt-Koyanagi-Harada (VKH) 类疾病的临床特征,该疾病是对抗癌治疗的次要.
- 评估这些患者的管理和结果.
主要方法:
- 追溯性,非干预性,多中心病例系列研究.
- 分析了17名患者 (34只眼睛),这些患者在抗癌治疗后出现了类似VKH的疾病.
- 收集的数据包括眼外和眼科特征,治疗,视觉结果和并发症.
主要成果:
- 17名患者中有14名患有皮肤黑色素瘤;常见的抗癌疗法包括BRAF/MEK和PD1抑制剂.
- 眼部症状,包括前腔炎,炎,下液和足部干扰,在治疗开始后16周内出现.
- 用高剂量口服皮质固醇治疗导致17名患者中16名患者的眼睛炎症得到控制,常见的并发症是白内障和眼睛高血压.
结论:
- 与新型抗癌疗法相关的VKH类特征呈现出明显的临床表型.
- 高剂量的系统性皮质类固醇是管理的基石,免疫调节疗法作为二线选择.
- 涉及瘤学家的多学科方法至关重要,考虑到可能需要调整抗癌治疗.
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